ارتباط بین گیرنده استروژن و پروژسترون با وضعیت قاعدگی در بیماران مبتلا به سرطان پستان مراجعه‌کننده به بیمارستان‌های قائم و امید مشهد

Background and Aim: Growth of breast cancer cells is often affected by the female sex steroids. Determination of the cellular concentrations of estrogen (ER) and progesterone (PR) receptors in the tumor is continuously used to predict which patients may benefit from antihormonal therapy. The rate of hormone receptor positivity is related to differentiation and type of tumor tissues, age and menstruation status of the patients. The aim of this study was to evaluate the relationship between the immunohistochemical results of ER and PR with clinico-pathologic features especially menstruation status in breast cancer patients in Mashhad. Materials and Methods: In an analytical observational study, during one year, 324 cases of breast cancer were evaluated immunohistochemically for ER & PR in the department of Radiation-Oncology and Pathology of Omid and Ghaem hospitals. The patients’ clinico-pathologic characteristics including age, sex, menstural status, histological type, and grade were obtained from pathological reports and physical examinations. Data were analyzed by SPSS 11.5, using chi-square at significant level of P<0.05. Results: Out of 324 patients, 170 cases (52.5%) were positive for ER and 161 cases (49.7%) of all tumors reacted positively for PR. From 217 premenupausal patients, 115 cases were estrogen receptor positive (52.9%) and there were 102 patients with negative estrogen receptor (47.1%). Frequency of ER positivity in post-menopausal mammary carcinoma was 47.6% (P=0.232). Also, 53% of all premenopausal and 43.9% of postmenopausal cases were PR positive (P=0.077). In 52.9% of cases, who were below 30 years, ER was positive (P=0.002). Conclusion: In various studies it has been found that ER and PR positive rate in postmenopausal women is more than premenopausal. According to the reversed results in our study, it is better that immunohistochemical methods be re-evaluated in reference laboratories since it seems that the common cause of this discrepancy is the difficulty in fixation and laboratory methods.